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LGD 4033 was developed with the goal of preventing muscle loss in the elderly and in those who suffer from muscle dystrophy. The product also had an anti-tissue growth factor (ATGF)-like effect.[5] It is well known that a lack of ATGF (artigenin) in the muscle is a risk factor for muscle atrophy,[6][7] and a deficiency in this protein is associated with reduced skeletal muscle mass.[8] The effects on muscle mass are believed to be secondary to at least in part a decrease in the levels of muscle soluble markers such as creatine kinase (CK) and protein levels of myoglobin.[5] There is a possible benefit associated with at least in part the decrease in muscle mass, although one study failed to find any effect on muscle strength[9] It is speculated that the benefits of at least in part at least in part the decrease in muscle mass may be due to the ATGF-like effects, and thus the product is known to be more effective than other supplements on muscle mass in elderly men without exercise-induced disease (ATGITD). Due to this inefficacy, DK-5015 is not approved by the Food and Drug Administration for use in the elderly, and has been replaced by A-543 in several studies. 7 Interactions with Hormones 7.1. Thyroid At least in mice, DK-5015 appears to produce an anti-thyroid effect at the dosage used in the study in rodents, although to a lesser extent than others.[10] This benefit is thought to be related to the reduction in the thyroid-stimulating peptide, TRPA1, suggesting thyroid hormone uptake into the cell.[10] The decrease in TRPA1 activity results in suppressed production of thyroid stimulating and inhibiting peptides from both the pituitary gland and the thyroid.[10] The use of DK-5015 has been correlated with some suppression of the thyroid hormones T4 and T3.[11] When looking at isolated human T3, there appears to be a reduction (albeit a small one) of the TRPV1 binding and the mRNA of the thyroid stimulating hormone, T4.[12] There may also be a suppression of the thyroid hormone T4 and T3 synthesis, but there is currently no conclusive evidence of that. 8 Safety and Toxicology 8.1. General One study using DK-5015 was unable to induce hypothyroidism or hypogonadism and noted that the supplementation was well-t Similar articles:
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